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Safety Information

ATIVAN® (lorazepam)

Indications and clinical use:

  • For the short-term relief of manifestations of excessive anxiety in patients with anxiety neurosis
  • As an adjunct for the relief of excessive anxiety that might be present prior to surgical interventions
  • Anxiety and tension associated with the stresses of everyday life usually do not require treatment with anxiolytic drugs


  • Myasthenia gravis
  • Acute narrow angle glaucoma
  • Hypersensitivity to benzodiazepines

Most serious warnings and precautions:

  • Severe anaphylactic/anaphylactoid reactions: If angioedema involves the tongue, glottis or larynx, airway obstruction may occur and be fatal. Patients who develop angioedema after treatment with a benzodiazepine should not be rechallenged with the drug

Other relevant warnings and precautions:

  • Alcohol use
  • Excessive sedation
    • Driving, operating heavy machinery not recommended
  • Caution in patients with compromised respiratory function
  • Fatal respiratory depression
  • Patients with pre-existing depression (may unmask suicidal tendencies)
  • Paradoxical reactions
  • Caution in the elderly, debilitated patients and those with organic brain syndrome
  • Risk of abuse potential (especially in patients with history of drug and/or alcohol abuse)
  • Physical and psychological dependence
  • Patients with mild to moderate hepatic or renal disease (monitor as necessary)
  • Patients with severe hepatic insufficiency and/or encephalopathy
  • Not recommended for:
    • Pediatrics
    • Concomitant use with other CNS depressants
    • Pregnant and nursing women
    • Women of child-bearing potential
    • Depressive neurosis or psychotic reactions
    • Patients with non-pathological anxiety
    • Patients with characterological and personality disorders
    • Patients with obsessive-compulsive neurosis
    • Patients with mental and emotional disorders
    • Long-term use

For more information:

Please consult the product monograph by clicking here for important information relating to adverse reactions (particularly dose dependent CNS reactions), drug interactions and dosing information which have not been discussed in this site.

ATIVAN ® Wyeth LLC, owner/Pfizer Canada Inc., Licensee